oxantel
Small moleculeexperimental
Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms. It has also been shown to inhibit fumarate reductase in some pathogenic bacteria. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
2
Earliest trial started Dec 1, 2010 (NCT01327469)
Timeline
Indications
Approved for
Mechanism of action
- Fumarate reductaseINHIBITOR
Fumarate reductase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCCN=C1/C=C/c1cccc(O)c1- Mol. weight
- 216.28 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaOxantel ↗
- ChEMBLCHEMBL1240977 ↗
Also known as
- 1,4,5,6-tetrahydro-2-(3-hydroxy styryl)-1-methylpyrimidine
- cp 14,445
- cp-14,445
- oxantel
- oxantel
- oxantel
- oxantel
- oxantel
- oxantel
- oxantel monohydrochloride, (e)-isomer
- oxantel tartrate
- oxantel tartrate (1:1), (r-(r*,r*))-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06720259 | Phase 2 | Feb 28, 2025 | University of Basel |
| NCT06606860 | Phase 1 | Nov 30, 2024 | Drugs for Neglected Diseases Initiative, Ifakara Health Institute, University of Basel |
| NCT03278431 | Phase 4 | Sep 27, 2017 | University of Basel |
| NCT01327469 | Phase 4 | Dec 1, 2010 | Ghent University, VLIR Institutional University Collaboration Programme |
Showing 4 of 4 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Basel | Academic/Hospital | 3 | 3 | 3 | 2017 |
| Drugs for Neglected Diseases Initiative | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Ghent University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Ifakara Health Institute | Academic/Hospital | 1 | 0 | 1 | 2024 |
| VLIR Institutional University Collaboration Programme | Academic/Hospital | 1 | 0 | 1 | 2010 |
5 organizations
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