hexadecylpyridinium
Cetylpyridinium (used in a form of chloride salt) is a cationic surface-active agent and has a broad antimicrobial spectrum, with rapid killing of gram-positive pathogens and yeast in particular. It is suggested that interaction with bacteria occurs by the disruption of membrane function, leakage of cytoplasmic material, and ultimately the collapse of the intra-cellular equilibrium. The drug is used under various trade names as an oral OTC hygiene product (mouthwash, dental kits, etc.) to control the dental plaque and to prevent the subsequent gingivitis. — NCATS
Clinical trial activity
3 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2013 (NCT02644135)
Timeline
2010s
- Jan 1, 2014
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Cetylpyridinium chloride (CPC) in a high bioactive mouth rinse matrix. CPC acts primarily by penetrating the bacterial cell membrane that causes leakage of cell components, disruption of bacterial metabolism, inhibition of cell growth, and finally cell death.
Chemistry & pharmacology
SMILES
CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1- Mol. weight
- 304.5331 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSCUB7JI0JV3 ↗
- ChEMBLCHEMBL34833 ↗
- ChEMBLCHEMBL305906 ↗
Also known as
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- cetylpyridinium
- hexadecylpyridinium
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02875769 | Phase 3 | Feb 1, 2015 | University of Guarulhos (UNG) |
| NCT02193165 | Phase 3 | Jul 1, 2014 | Colgate Palmolive |
| NCT02644135 | N/A | Jan 1, 2013 | Case Western Reserve University |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Colgate Palmolive | For profit | 1 | 1 | 1 | 2014 |
| University of Guarulhos (UNG) | Academic/Hospital | 1 | 1 | 1 | 2015 |