hexadecylpyridinium

Small moleculeexperimental

Cetylpyridinium (used in a form of chloride salt) is a cationic surface-active agent and has a broad antimicrobial spectrum, with rapid killing of gram-positive pathogens and yeast in particular. It is suggested that interaction with bacteria occurs by the disruption of membrane function, leakage of cytoplasmic material, and ultimately the collapse of the intra-cellular equilibrium. The drug is used under various trade names as an oral OTC hygiene product (mouthwash, dental kits, etc.) to control the dental plaque and to prevent the subsequent gingivitis. — NCATS

Clinical trial activity

3 trials · 3 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
0

Earliest trial started Jan 1, 2013 (NCT02644135)

Timeline

2010s

  1. Jan 1, 2014

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetOTHER

    Unknown

    Cetylpyridinium chloride (CPC) in a high bioactive mouth rinse matrix. CPC acts primarily by penetrating the bacterial cell membrane that causes leakage of cell components, disruption of bacterial metabolism, inhibition of cell growth, and finally cell death.

Chemistry & pharmacology

Loading structure…

SMILES

CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1
Mol. weight
304.5331 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • cetylpyridinium
  • hexadecylpyridinium

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02875769Phase 3Feb 1, 2015University of Guarulhos (UNG)
NCT02193165Phase 3Jul 1, 2014Colgate Palmolive
NCT02644135N/AJan 1, 2013Case Western Reserve University
Showing 3 of 3 trials
Page 1 / 1

Organizations

Research & Development (3)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Case Western Reserve UniversityAcademic/Hospital1112013
Colgate PalmoliveFor profit1112014
University of Guarulhos (UNG)Academic/Hospital1112015
3 organizations
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