cytotoxic t cells
Cell therapyexperimental
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or cells that are damaged in other ways. — Wikipedia
Clinical trial activity
19 trials · 32 clinical orgs · 0 marketing orgs
Phase 1
9
Phase 2
8
Phase 3
5
Phase 4
0
Earliest trial started May 1, 2007 (NCT00473551)
Timeline
Indications
Studied for
- Acquired Immunodeficiency Syndrome · Phase 2
- Adenoviridae · Phase 1
- Adenoviridae Infections · Phase 1
- BK Virus · Phase 2
- Carcinoma, Merkel Cell · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Carcinoma, Pancreatic Ductal · Phase 1/Phase 2
- Cytomegalovirus Infections · Phase 2
- Encephalitis, Viral · Phase 2
- Epstein-Barr Virus Infections · Phase 2
- Glioblastoma · Phase 2/Phase 3
- Herpesvirus 4, Human · Phase 1
- HIV · Phase 2
- HIV Infections · Phase 3
- JC Virus · Phase 2
- Leukemia · Phase 1
- Lymphoma · Phase 2
- Melanoma · Phase 1/Phase 2
- Multiple Myeloma · Phase 1
- Neoplasm Metastasis · Phase 2/Phase 3
- Neoplasms · Phase 2
- Primary Immunodeficiency Diseases · Phase 2
- Stomach Neoplasms · Phase 1/Phase 2
Mechanism of action
- T-lymphocytesSupplementation
T-lymphocytes supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCytotoxic T cell ↗
- WikipediaCTL ↗
Also known as
- ctl
- ctl
- cytolytic t-lymphocytes
- cytotoxic lymphocytes
- cytotoxic t cells
- cytotoxic t lymphocytes
- cytotoxic t-lymphocytes
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07225972 | Phase 3 | Dec 1, 2026 | New York Medical College |
| NCT06916936 | N/A | Feb 9, 2025 | Florida State University, The Peanut Institute |
| NCT05574413 | N/A | Sep 15, 2022 | University of British Columbia |
| NCT04567069 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2020 | Shandong University, Shanghai Sunstem Biotechnology Co., Ltd. |
| NCT04193098 | Phase 1 | Jun 1, 2019 | Tianjin Medical University |
| NCT03266653 | Phase 2 | May 1, 2018 | Medical College of Wisconsin, New York Medical College, University of Pennsylvania |
| NCT03060343 | Early Phase 1 (Phase 1) | Nov 28, 2016 | Central South University, Hunan Yongren Medical Innovation Co. Ltd., Hunan Zhaotai Yongren Biotech Co. Ltd. |
| NCT02496273 | Phase 1 | Jan 1, 2016 | The First People's Hospital of Changzhou |
| NCT02479698 | Phase 2 | Jul 1, 2015 | University of Texas at Houston |
| NCT02529579 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2015 | Changhai Hospital, ImmunoGenes, People's Liberation Army of China |
| NCT02210078 | Phase 2 | Feb 1, 2015 | Miltenyi Biotec, Inc., University of Texas at Houston |
| NCT02231281 | Phase 3 | Aug 1, 2014 | Capital Medical University, China Medical University, Government of China, Guangxi Medical University, People's Liberation Army of China, Zhejiang University |
| NCT01923766 | Phase 1 | Sep 1, 2013 | Children's National Medical Center, University of Texas at Houston |
| NCT01759810 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2012 | Blokhin's Russian Cancer Research Center, NeuroVita Clinic, Russian Foundation of Technological Development, SRC Bioclinicum, The Serbsky State Scientific Center for Social and Forensic Psychiatry, ZAO NeuroVita Clinic of Interventional and Restorative Neurology and Therapy |
| NCT01782287 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2012 | Blokhin's Russian Cancer Research Center, NeuroVita Clinic, Russian Foundation of Technological Development, SRC Bioclinicum, The Serbsky State Scientific Center for Social and Forensic Psychiatry, ZAO NeuroVita Clinic of Interventional and Restorative Neurology and Therapy |
| NCT01782274 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2012 | Blokhin's Russian Cancer Research Center, NeuroVita Clinic, Russian Foundation of Technological Development, SRC Bioclinicum, The Serbsky State Scientific Center for Social and Forensic Psychiatry, ZAO NeuroVita Clinic of Interventional and Restorative Neurology and Therapy |
| NCT01535885 | Phase 1 | Feb 1, 2012 | Medical College of Wisconsin |
| NCT00871481 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2009 | National Cancer Institute (NCI), University of Washington |
| NCT00473551 | Phase 1 | May 1, 2007 | University of Texas at Houston |
Showing 19 of 19 trials
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Organizations
Research & Development (32)
32 organizations
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