ketoglutarate
Small moleculeexperimental
α-Ketoglutaric acid is an organic compound with the formula HO2CCO(CH2)2CO2H. A white, nontoxic solid, it is a common dicarboxylic acid. Relevant to its biological roles, it exists in water as its conjugate base α-ketoglutarate. It is also classified as a 2-ketocarboxylic acid. β-Ketoglutaric acid is an isomer. "Ketoglutaric acid" and "ketoglutarate", when not qualified as α or β, almost always refers respectively to α-ketoglutaric acid or α-ketoglutarate. — Wikipedia
Clinical trial activity
11 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
5
Phase 3
1
Phase 4
1
Earliest trial started Aug 1, 2012 (NCT01681095)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaΑ-Ketoglutaric acid ↗
- WikipediaAlpha-Ketoglutaric acid ↗
Also known as
- ketoglutarate
- ketoglutarate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07114536 | N/A | Aug 20, 2025 | Government of China, Zhejiang Chinese Medical University |
| NCT07031128 | Phase 4 | Jun 11, 2024 | National University of Singapore, Wellcome Trust |
| NCT06414330 | N/A | Jun 1, 2024 | Assiut University |
| NCT06646809 | Phase 3 | May 9, 2024 | Government of Singapore, National University of Singapore |
| NCT07269704 | Phase 1 | Aug 15, 2023 | Stanford University |
| NCT05706389 | Phase 2 | Feb 24, 2023 | Agency for Science, Technology and Research, AMILI Pte. Ltd., National University of Singapore |
| NCT04723888 | N/A | Feb 1, 2021 | Jiao Tong University |
| NCT04821401 | N/A | Feb 7, 2020 | Ponce De Leon Health |
| NCT03082716 | Phase 2 | Sep 19, 2016 | King Faisal University |
| NCT02618824 | Phase 2 | Dec 1, 2015 | University of Indonesia |
| NCT01681095 | Phase 2 | Aug 1, 2012 | Essential Pharmaceuticals, LLC, Oakland University, United States Army, William Beaumont Hospitals |
Showing 11 of 11 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National University of Singapore | Academic/Hospital | 3 | 3 | 3 | 2023 |
| Agency for Science, Technology and Research | Government | 1 | 0 | 1 | 2023 |
| AMILI Pte. Ltd. | For profit | 1 | 0 | 1 | 2023 |
| Assiut University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Essential Pharmaceuticals, LLC | For profit | 1 | 0 | 1 | 2012 |
| Government of China | Government | 1 | 1 | 1 | 2025 |
| Government of Singapore | Government | 1 | 0 | 1 | 2024 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| King Faisal University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Oakland University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Ponce De Leon Health | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Stanford University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| United States Army | Government | 1 | 0 | 1 | 2012 |
| University of Indonesia | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Wellcome Trust | Academic/Hospital | 1 | 0 | 1 | 2024 |
| William Beaumont Hospitals | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Zhejiang Chinese Medical University | Academic/Hospital | 1 | 0 | 1 | 2025 |
17 organizations
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