hydrastis canadensis

Botanicalexperimental

Goldenseal, also called orangeroot or yellow puccoon, is a perennial herb in the buttercup family Ranunculaceae, native to North America. It may be distinguished by its thick, yellow knotted rootstock. The stem is purplish and hairy above ground and yellow below ground where it connects to the yellow rhizome. Goldenseal reproduces both clonally through the rhizome and sexually, with clonal division more frequent than asexual reproduction. It takes between 4 and 5 years for a plant to reach sexual maturity, i.e. the point at which it produces flowers. Plants in the first stage, when the seed erupts and cotyledons emerge, can remain in this state one or more years. The second vegetative stage occurs during years two and three and is characterized by the development of a single leaf and absence of a well developed stem. Finally, the third stage is reproductive, at which point flowering and fruiting occurs. This last stage takes between 4 and 5 years to develop. — Wikipedia

Clinical trial activity

2 trials · 3 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
1
Phase 3
1
Phase 4
0

Earliest trial started Oct 1, 2013 (NCT02345447)

Timeline

2010s

  1. Jan 1, 2013

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2021

    Earliest Phase 1 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • hydrastis canadensis

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05081583Early Phase 1 (Phase 1)Sep 16, 2021National Center for Complementary and Integrative Health (NCCIH), Washington State University
NCT02345447Phase 3Oct 1, 2013University of Tuebingen
Showing 2 of 2 trials
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Organizations

Research & Development (3)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Center for Complementary and Integrative Health (NCCIH)Government1012021
University of TuebingenAcademic/Hospital1112013
Washington State UniversityAcademic/Hospital1112021
3 organizations
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