eukalyptol

Small moleculeexperimental

Eucalyptol is a natural organic compound with fresh mint-like smell and a spicy, cooling taste. Eucalyptol comprises up to 90 percent of the essential oil of some species of the generic product Eucalyptus oil, hence the common name of the compound. It is also found in camphor laurel, bay leaves, tea tree, mugwort, sweet basil, wormwood, rosemary, common sage, Cannabis sativa and other aromatic plant foliage. Eucalyptol with a purity from 99.6 to 99.8 percent can be obtained in large quantities by fractional distillation of eucalyptus oil. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant, as well as an inactive ingredient in body powder. The typical concentrations of eucalyptol in cosmetic products have been reported to be 1.6% in perfume, 0.4% in soap, 0.1% in creams and lotions and 0.04% in detergents. Committee of Experts on Flavouring Substances of the Council of Europe (CEFS) proposed upper levels of 0.1 mg/kg in beverages and 5 mg/kg in food with the exception of 15 mg/kg in candy and confectionery and 50 mg/kg in alcoholic beverages. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. — NCATS

Clinical trial activity

2 trials · 3 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
0

Earliest trial started May 1, 2011 (NCT01119534)

Timeline

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

CC12CCC(CC1)C(C)(C)O2
Mol. weight
154.2493 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1,8-cineol
  • 1,8-cineol
  • 1,8-cineol
  • 1,8-cineole
  • 1,8-cineole
  • 1,8-cineole
  • 1,8-epoxy-p-menthane
  • 1,8-epoxy-p-menthane
  • 1,8-epoxy-p-menthane
  • 1,8-oxido-p-menthane
  • 1,8-oxido-p-menthane
  • cajeputol
  • cajeputol
  • cineol
  • cineol
  • cineol
  • cineole
  • cineole
  • cineole
  • cineole
  • cineole
  • cineole
  • cucalyptol
  • cucalyptol
  • eucaliptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptol
  • eucalyptole
  • eucalyptus
  • eucalyptus
  • eucalytol
  • eucapur
  • eucapur
  • eukalyptol
  • soledum
  • zineol
  • zineol

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02874963N/ANov 1, 2015University Clinical Centre of Kosova, University of Ljubljana
NCT01119534Phase 3May 1, 2011Azidus
Showing 2 of 2 trials
Page 1 / 1

Organizations

Research & Development (3)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AzidusFor profit1112011
University Clinical Centre of KosovaAcademic/Hospital1112015
University of LjubljanaAcademic/Hospital1012015
3 organizations
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