milk thistle
Botanicalexperimental
Silybum marianum is a species of thistle. It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle. This species is an annual or biennial plant of the family Asteraceae. This fairly typical thistle has red to purple flowers and shiny pale green leaves with white veins. Once native from Southern Europe through Asia, it has spread throughout the world. — Wikipedia
Clinical trial activity
9 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
7
Phase 3
1
Phase 4
0
Earliest trial started Jun 1, 2009 (NCT01001845)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSilybum marianum ↗
- NCATSU946SH95EE ↗
- ChEMBLCHEMBL2108623 ↗
Also known as
- isagenesis
- milk thistle
- milk thistle
- milk thistle
- milk thistle extract
- milk thistle extract
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06477146 | Phase 2 | Sep 9, 2024 | Case Western Reserve University |
| NCT04717726 | Phase 3 | Feb 24, 2021 | University of Kentucky |
| NCT02843451 | Phase 2 | Oct 1, 2016 | University of Chicago |
| NCT02529605 | N/A | Sep 1, 2015 | Isagenix International LLC, University of Florida |
| NCT02473913 | Phase 2 | Mar 1, 2015 | University of Chicago |
| NCT02337634 | Phase 2 | Jan 1, 2015 | University of Chicago |
| NCT01239095 | Phase 1 | Jul 1, 2011 | Icahn School of Medicine at Mount Sinai, St. Luke's-Roosevelt Hospital Center |
| NCT01003236 | Phase 2 | Oct 1, 2010 | University of Tehran |
| NCT01001845 | Phase 2 | Jun 1, 2009 | University of Tehran |
Showing 9 of 9 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Chicago | Academic/Hospital | 3 | 3 | 1 | 2015 |
| University of Tehran | Academic/Hospital | 2 | 2 | 1 | 2009 |
| Case Western Reserve University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Isagenix International LLC | For profit | 1 | 0 | 1 | 2015 |
| St. Luke's-Roosevelt Hospital Center | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Florida | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Kentucky | Academic/Hospital | 1 | 1 | 1 | 2021 |
8 organizations
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