hypericin

Trade name: sgx301

Small moleculeexperimental

Hypericin is a carbopolycyclic compound derived from bisanthene with antidepressant properties, found in various Hypericum species, and is being studied for treating cutaneous T-cell lymphoma. — Wikipedia

Clinical trial activity

9 trials · 6 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
7
Phase 3
3
Phase 4
0

Earliest trial started Nov 2, 1999 (NCT00000645)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2012

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2022

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65
Mol. weight
504.45 g/mol
Lipinski Ro5
3 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione
  • hipericin
  • hypericin
  • hypericin
  • hypericin
  • hypericin
  • mono-(123i)iodohypericin
  • sgx301

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06470451Phase 3Oct 31, 2024Soligenix
NCT06149247Phase 2Dec 5, 2023Soligenix
NCT05872854Phase 2Aug 21, 2023Soligenix, University of Pennsylvania
NCT05442190Phase 2Dec 14, 2022Soligenix
NCT05380635Phase 2May 9, 2022Soligenix
NCT02448381Phase 3Dec 1, 2015Soligenix
NCT01365676Phase 3Mar 1, 2012Federal University of Health Science of Porto Alegre, Phytopharm
NCT00000645Phase 1Nov 2, 1999National Institute of Allergy and Infectious Diseases (NIAID), Nexell Therapeutics
NCT00000792Phase 1Nov 2, 1999National Institute of Allergy and Infectious Diseases (NIAID), Nexell Therapeutics
Showing 9 of 9 trials
Page 1 / 1

Organizations

Research & Development (6)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
SoligenixFor profit6522015
National Institute of Allergy and Infectious Diseases (NIAID)Government2211999
Nexell TherapeuticsFor profit2011999
Federal University of Health Science of Porto AlegreAcademic/Hospital1012012
PhytopharmFor profit1112012
University of PennsylvaniaAcademic/Hospital1112023
6 organizations
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