hexetidine
Trade name: hexoral
Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient. These characteristics give important therapeutic role in treatment of oral infections. In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. Oraldene contains 0.1 g/100 ml of hexetidine. In Germany, hexetidine is used for vaginal antisepsis. — NCATS
Clinical trial activity
1 trials · 1 clinical orgs · 0 marketing orgs
Earliest trial started Feb 1, 2010 (NCT01115049)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Mechanism of action
- Cell membraneDISRUPTING AGENT
Cell membrane disrupting agent
Chemistry & pharmacology
SMILES
CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1- Mol. weight
- 339.6021 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaHexetidine ↗
- NCATS852A84Y8LS ↗
- ChEMBLCHEMBL144673 ↗
Also known as
- esetidina
- esetidina
- glypesin
- hexetedine
- hexetidine
- hexetidine
- hexetidine
- hexetidine
- hexetidine
- hexetidine
- hexetidine
- hexetidine
- hexétidine
- hexétidine
- hexopyrimidine
- hexopyrimidine
- hexoral
- oraldene
- oraldene
- sterisil
- sterisil
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01115049 | Phase 4 | Feb 1, 2010 | University of Naples Frederico II |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Naples Frederico II | Academic/Hospital | 1 | 1 | 1 | 2010 |