pyrequan
Small moleculeexperimental
Pyrantel is an anthelmintic, which acts as an agonist of nicotinic receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. It is used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis and trichinellosis. Common adverse reactions include diarrhea, nausea, vomiting, dizziness, headache and somnolence. — NCATS
Clinical trial activity
3 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
2
Earliest trial started Dec 1, 2010 (NCT01327469)
Timeline
No events for the selected filters.
Indications
Approved for
Mechanism of action
- Ascaris suumINHIBITOR
Ascaris suum inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCCN=C1\C=C\C2=CC=CS2- Mol. weight
- 206.307 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS4QIH0N49E7 ↗
- ChEMBLCHEMBL1626223 ↗
- ChEMBLCHEMBL1599768 ↗
- ChEMBLCHEMBL1585303 ↗
Also known as
- pyrantel
- pyrantel
- pyrantel
- pyrantel
- pyrantel
- pyrantel
- pyrantel
- pyrantel
- pyrantel pamoate
- pyrantel tartrate
- pyrequan
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03278431 | Phase 4 | Sep 27, 2017 | University of Basel |
| NCT02812615 | N/A | Jun 1, 2016 | Bangladesh Medical University, Bill and Melinda Gates Foundation, Dhaka Medical College, International Center for Diarrheal Disease Research, University of Virginia, University of Washington |
| NCT01327469 | Phase 4 | Dec 1, 2010 | Ghent University, VLIR Institutional University Collaboration Programme |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bangladesh Medical University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Bill and Melinda Gates Foundation | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Dhaka Medical College | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Ghent University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| International Center for Diarrheal Disease Research | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Basel | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Virginia | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of Washington | Academic/Hospital | 1 | 0 | 1 | 2016 |
| VLIR Institutional University Collaboration Programme | Academic/Hospital | 1 | 0 | 1 | 2010 |
9 organizations
Page 1 / 1