whole-cell pertussis vaccine
Pertussis vaccine is a vaccine that protects against whooping cough (pertussis). There are two main types: whole-cell vaccines and acellular vaccines. The whole-cell vaccine is about 78% effective while the acellular vaccine is 71–85% effective. The effectiveness of the vaccines appears to decrease by between 2 and 10% per year after vaccination, with a more rapid decrease with the acellular vaccines. The vaccine is only available in combination with tetanus and diphtheria vaccines. Pertussis vaccine is estimated to have saved over 500,000 lives in 2002. — Wikipedia
Clinical trial activity
2 trials · 8 clinical orgs · 0 marketing orgs
Earliest trial started Apr 1, 1991 (NCT00004799)
Timeline
1990s
- Jan 1, 1991
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- Bordetella pertussisImmunity, active
Bordetella pertussis immunity, active
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPertussis vaccine ↗
Also known as
- whole-cell pertussis vaccine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03606096 | Phase 4 | Sep 30, 2018 | Imperial College London, Leiden University, National Institute for Public Health and the Environment, RIVM, Holland, Radboud University, University of London, University of Oxford, University of Turku |
| NCT00004799 | Phase 3 | Apr 1, 1991 | National Institute of Allergy and Infectious Diseases (NIAID) |
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Imperial College London | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Leiden University | Academic/Hospital | 1 | 0 | 1 | 2018 |
| National Institute for Public Health and the Environment, RIVM, Holland | Government | 1 | 0 | 1 | 2018 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 1991 |
| Radboud University | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Oxford | Academic/Hospital | 1 | 0 | 1 | 2018 |
| University of Turku | Academic/Hospital | 1 | 0 | 1 | 2018 |