valine
Small moleculeexperimental
Valine is an α-amino acid that is used in the biosynthesis of proteins. It is essential in humans, meaning the body cannot synthesize it and thus it must be obtained from the diet. There is a mixed scientivic evidence that as a dietary supplement valine improves training efficacy, delays central fatigue. — NCATS
Clinical trial activity
4 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
1
Earliest trial started Apr 1, 2007 (NCT01434524)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Mechanism of action
- Valyl-tRNA synthetase 2SUBSTRATE
VARS1 substrate
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)[C@H](N)C(O)=O- Mol. weight
- 117.1463 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaValine ↗
- NCATSHG18B9YRS7 ↗
- ChEMBLCHEMBL43068 ↗
Also known as
- 2-amino-3-methylbutyric acid
- 2-amino-3-methylbutyric acid
- (2s)-2-amino-3-methylbutanoic acid
- (2s)-2-amino-3-methylbutanoic acid
- l-alpha-amino-beta-methylbutyric acid
- l-alpha-amino-beta-methylbutyric acid
- l-(+)-alpha-aminoisovaleric acid
- l-(+)-alpha-aminoisovaleric acid
- l-valine
- l-valine
- l-valine
- l-valine
- l-valine
- (s)-valine
- (s)-valine
- val
- val
- valine
- valine
- valine
- valine
- valine
- valine
- valine
- valine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03180775 | N/A | Jul 1, 2017 | Technion University |
| NCT02837302 | Phase 4 | Nov 1, 2012 | Kyungpook University, Samil Pharmaceutical Co., Ltd. |
| NCT01495871 | N/A | Nov 1, 2011 | The Moody Foundation, University of Texas, Galveston |
| NCT01434524 | N/A | Apr 1, 2007 | Kochi University |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Kochi University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Kyungpook University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Samil Pharmaceutical Co., Ltd. | For profit | 1 | 0 | 1 | 2012 |
| Technion University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| The Moody Foundation | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Texas, Galveston | Academic/Hospital | 1 | 1 | 1 | 2011 |
6 organizations
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