sarcosine
Small moleculeexperimental
Sarcosine, also known as N-methylglycine, or monomethylglycine, is a amino acid with the formula CH3N(H)CH2CO2H. It exists at neutral pH as the zwitterion CH3N+(H)2CH2CO2−, which can be obtained as a white, water-soluble powder. Like some amino acids, sarcosine converts to a cation at low pH and an anion at high pH, with the respective formulas CH3N+(H)2CH2CO2H and CH3N(H)CH2CO2−. Sarcosine is a close relative of glycine, with a secondary amine in place of the primary amine. — Wikipedia
Clinical trial activity
11 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
8
Phase 3
0
Phase 4
1
Earliest trial started Dec 1, 2004 (NCT00328276)
Timeline
2000s
- Jan 1, 2004
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
CNCC(=O)O- Mol. weight
- 89.09 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSarcosine ↗
- ChEMBLCHEMBL304383 ↗
Also known as
- glyt-1 inhibitor-1
- n-methyl glycine
- n-methyl glycine
- sarcosine
- sarcosine
- sarcosine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04975100 | Phase 4 | Aug 26, 2021 | All India Institute of Medical Sciences |
| NCT01503359 | Phase 2 | Jan 1, 2012 | Medical University of Lodz |
| NCT01785628 | N/A | Aug 1, 2010 | China Medical University, Government of Taiwan |
| NCT01251055 | Phase 2 | Apr 1, 2010 | China Medical University |
| NCT00977353 | Phase 2 | Apr 1, 2009 | China Medical University, Government of Taiwan |
| NCT01047592 | Phase 2 | Mar 1, 2009 | Changhua Hospital, China Medical University |
| NCT00538070 | N/A | Aug 1, 2007 | Harvard University, Mclean Hospital, National Institute on Drug Abuse (NIDA) |
| NCT01031927 | Phase 2 | Jun 1, 2007 | China Medical University, Taipei Medical University, University of California, Los Angeles |
| NCT00276263 | Phase 2 | Aug 1, 2006 | Hebrew University, Herzog Hospital |
| NCT00491569 | Phase 2 | Jan 1, 2005 | China Medical University, Government of Taiwan |
| NCT00328276 | Phase 2 | Dec 1, 2004 | China Medical University, Government of Taiwan, University of California, Los Angeles |
Showing 11 of 11 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| China Medical University | Academic/Hospital | 7 | 6 | 2 | 2004 |
| Government of Taiwan | Government | 4 | 0 | 2 | 2004 |
| University of California, Los Angeles | Academic/Hospital | 2 | 0 | 1 | 2004 |
| All India Institute of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Changhua Hospital | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Hebrew University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Herzog Hospital | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Mclean Hospital | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Medical University of Lodz | Academic/Hospital | 1 | 1 | 1 | 2012 |
| National Institute on Drug Abuse (NIDA) | Government | 1 | 0 | 1 | 2007 |
| Taipei Medical University | Academic/Hospital | 1 | 0 | 1 | 2007 |
12 organizations
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