cinnamaldehyde
Cinnamaldehyde is one of the active compounds found in cinnamon. It was reported that cinnamaldehyde has anti-diabetic, anti-cancer, antimicrobial and anti-inflammatiry activity. Cinnamon is a common prescription compound in traditional Chinese medicine and it is used as a dietary supplement all over the world. Cinnamon dietary supplement Cinnamonforce (min. 35% cinnamaldehyde) was tested in phase II clinical trials and demonstrated therapeutic activity in patients with type 2 diabetes. The mechanism of cinnamaldehyde possibly involves the activation of PPAR gamma/delta receptors. Cinnamaldehyde is partially metabolized into cinnamic acid in the stomach and small intestine, and is almost completely metabolized into cinnamic acid in the liver. Cinnamic acid is believed to be the active metabolite, which is responsible for anti-diabetic properties of cinnamaldehyde. — NCATS
Clinical trial activity
6 trials · 5 clinical orgs · 0 marketing orgs
Earliest trial started Feb 1, 2011 (NCT01667523)
Timeline
No events for the selected filters.
Indications
Studied for
Chemistry & pharmacology
SMILES
O=C\C=C\C1=CC=CC=C1- Mol. weight
- 132.1592 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCinnamaldehyde ↗
- NCATSSR60A3XG0F ↗
Also known as
- 3-phenylprop-2-enaldehyde
- beta-phenylacrolein
- cinnamaldehyde
- cinnamaldehyde
- cinnamaldehyde
- cinnamic aldehyde
- cinnamic aldehyde
- cinnamic aldehyde
- cinnamic aldehyde, (e)-isomer
- supercinnamaldehyde
- trans-3-phenylprop-2-enaldehyde
- trans-cinnamaldehyde
- trans-cinnamaldehyde
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06036589 | N/A | Mar 10, 2022 | Aalborg University |
| NCT04415892 | N/A | Oct 1, 2019 | Katholieke Universiteit Leuven |
| NCT03943407 | N/A | Jun 30, 2019 | Aalborg University |
| NCT04741620 | N/A | Jan 17, 2019 | Hospital de Mataró |
| NCT03132142 | N/A | Apr 1, 2017 | Aalborg University |
| NCT01667523 | N/A | Feb 1, 2011 | Maastricht University, Top Institute Food and Nutrition |
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aalborg University | Academic/Hospital | 3 | 3 | 1 | 2017 |
| Hospital de Mataró | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Katholieke Universiteit Leuven | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Top Institute Food and Nutrition | Academic/Hospital | 1 | 0 | 1 | 2011 |